circRNA basic information
circBase ID: hsa_circ_0008324
Name: hsa_circ_EZH2
Synonym: circEZH2E2‐E4
Host Gene: EZH2
Genomic location(hg19): chr7:148529725-148544397:-
Genomic location(hg38): chr7:148832633-148847305:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate cancer tissue samples; BPH tissue samples
Cell lines:

DU145; PC-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

circEZH2E2-E4 (hsa_circ_0008324) is one of the EZH2-derived circRNAs detected in prostate cancer cell lines and is overexpressed in PCa cells and tissue samples. No functional/mechanistic or clinical analyses were reported for this circRNA beyond expression profiling.
Confidence score:

0.5129
Other information
Title:

circEZH2E2 /E3 is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression.

Journal: Cancer science
Published: 2023
PubMed ID: 36519785
Study type:

combined biological and clinical study
Data availability: -
Code availability: -