| Expression pattern: |
UP |
| Associated gene: |
XPR1, HN1 |
| Associated microRNA: |
miR-493-3p |
| Biological function: |
promotes gastric cancer cell proliferation, migration and invasion; promotes EMT; inhibits apoptosis; facilitates M2 macrophage polarization; promotes tumor growth in vivo |
| Molecular mechanism: |
acts as a ceRNA (miRNA sponge) for miR-493-3p to upregulate XPR1; promotes macrophage M2 polarization to enhance EMT and malignant phenotypes |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); immune regulation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; ELISA; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circRNA_102191 is suggested as an important biomarker for the occurrence and development of gastric cancer |
| Description: |
circRNA_102191 is up-regulated in gastric cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion, EMT) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-493-3p to increase XPR1 expression and also enhances M2 macrophage polarization, which further supports EMT and tumor progression. |
| Confidence score: |
0.7898 |