circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

Hela; HepG2; MCF-7; L-02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Serves as a potential biomarker for diagnosis and prognosis of hepatocellular carcinoma; this study detected lower circMTO1 expression in HCC patient whole blood and HepG2 cells.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

Potential diagnostic and prognostic biomarker for HCC; lower circMTO1 expression was detected in whole blood samples from HCC patients compared with healthy individuals.
Description:

This study developed a CHA-PER-DNAzyme fluorescence assay for ultrasensitive and specific detection of circMTO1. circMTO1 was detected at lower levels in HepG2 liver cancer cells and in whole blood from HCC patients compared with controls, supporting its potential clinical utility as an HCC-associated biomarker.
Confidence score:

0.2995
Other information
Title:

Triple Amplification Strategy of CHA-PER-DNAzyme for Ultrasensitive Detection of circRNA Associated with Hepatocellular Carcinoma.

Journal: Analytical chemistry
Published: 2023
PubMed ID: 37607407
Study type:

combined biological and clinical study
Data availability: Supporting Information available at https://pubs.acs.org/doi/10.1021/acs.analchem.3c01951
Code availability: -