circRNA basic information
circBase ID: hsa_circ_0003288
Name: hsa_circ_BIRC6
Synonym: circ_0003288
Host Gene: BIRC6
Genomic location(hg19): chr2:32703702-32718734:+
Genomic location(hg38): chr2:32478634-32493667:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent normal tissues; lung cancer tissues
Cell lines:

NCI-H460; A549; NCI-H1650; NCI-H1299; HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-145
Biological function: hsa_circ_0003288 promotes NSCLC cell proliferation, colony formation, migration, invasion and tumor growth, and inhibits apoptosis.
Molecular mechanism: hsa_circ_0003288 acts as an oncogene by directly targeting and negatively regulating miR-145.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; TUNEL; In Vivo Animal Model
Clinical significance:

hsa_circ_0003288 is significantly elevated in NSCLC tissues and may provide a novel therapeutic target for treatment of lung cancer.
Description:

hsa_circ_0003288 is up-regulated in NSCLC tissues and lung cancer cell lines. It functions as an oncogenic circRNA that promotes proliferation, colony formation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, it directly targets and negatively regulates miR-145, forming a hsa_circ_0003288/miR-145 axis in NSCLC progression.
Confidence score:

0.6536
Other information
Title:

Hsa_circ_0003288 facilitates tumor progression by targeting miR-145 in non-small cell lung cancer cells.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2022
PubMed ID: 35001875
Study type:

combined biological and clinical study
Data availability: -
Code availability: -