| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0003570 was decreased in HCC cell lines and tissues, gradually decreased from CH to LC to HCC, associated with HCC clinicopathological characteristics, and suggested to potentially play roles during HCC invasion and metastasis. |
| Molecular mechanism: |
No direct molecular mechanism was experimentally demonstrated; the circRNA is transcribed from FAM53B, whose protein is described as modulating cell proliferation and regulating beta-catenin-dependent Wnt signaling. |
| Biological pathway or process: |
invasion (inhibits); metastasis (inhibits); proliferation (other); Wnt/beta-catenin (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
hsa_circ_0003570 expression levels were associated with HCC clinicopathological characteristics including tumor diameter, differentiation, microvascular invasion, BCLC stage, TNM stage, and serum AFP levels; ROC analysis suggested poor performance for differentiating HCC from LC and CH but relatively good performance for differentiating LC from CH. |
| Description: |
This study showed that hsa_circ_0003570 is significantly down-regulated in HCC cell lines and HCC tissues, with expression decreasing across CH, LC, and HCC. Its reduced expression is associated with clinicopathological features of HCC and may have clinical relevance as a biomarker, especially for distinguishing LC from CH, although mechanistic function was not experimentally validated. |
| Confidence score: |
0.63 |