| Expression pattern: |
UP |
| Associated gene: |
CDKL3 |
| Associated microRNA: |
miR-876-3p |
| Biological function: |
Promotes colorectal cancer cell proliferation, migration, invasion and xenograft tumor growth, and reduces apoptosis. |
| Molecular mechanism: |
ceRNA mechanism: circTP53 acts as a sponge for miR-876-3p and increases CDKL3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
circTP53 could serve as a potential predictive biomarker and potential drug target for colorectal cancer treatment. |
| Description: |
circTP53 is up-regulated in colorectal cancer tissues and colorectal carcinoma cell lines. It promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, functioning through a ceRNA mechanism in which circTP53 sponges miR-876-3p to elevate CDKL3 expression. |
| Confidence score: |
0.7552 |