circRNA basic information
circBase ID: hsa_circ_0001895
Name: hsa_circ_PRRC2B
Synonym: hsa_circ_000760
Host Gene: PRRC2B
Genomic location(hg19): chr9:134305476-134308181:+
Genomic location(hg38): chr9:131430089-131432794:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent non-tumorous tissues; healthy gastric mucosa; gastric dysplasia tissues
Cell lines:

GES-1; AGS; BGC-823; HGC-27; MGC-803; SGC-7901
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0001895 may play crucial roles during gastric cancerogenesis and may serve as a potential biomarker for screening, diagnostic evaluation, and clinical prognosis prediction.
Molecular mechanism: -
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0001895 expression was significantly correlated with cell differentiation, Borrmann type, and tissue carcino-embryonic antigen expression; ROC analysis showed diagnostic value for differentiating gastric cancer tissues from healthy controls; it may be a potential biological molecule for clinical prognosis prediction.
Description:

This study found that hsa_circ_0001895 is significantly down-regulated in gastric cancer cell lines, gastric cancer tissues, and gastric dysplasia tissues. Its expression is associated with clinicopathological factors including cell differentiation, Borrmann type, and tissue CEA expression, and ROC analysis supports its potential diagnostic value. The article proposes hsa_circ_0001895 as a potential biomarker for gastric cancer screening and prognosis prediction, but does not define a specific molecular mechanism.
Confidence score:

0.6238
Other information
Title:

Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Published: 2017
PubMed ID: 28443463
Study type:

combined biological and clinical study
Data availability: CircBase database; http://cir-crna.org/
Code availability: -