circRNA basic information
circBase ID: hsa_circ_0055521
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:86433228-86434450:+
Genomic location(hg38): chr2:86206105-86207327:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FAP
Associated microRNA: hsa-miR-204-5p
Biological function: May influence the onset, progression, and prognosis of gastric cancer via a ceRNA mechanism affecting FAP expression.
Molecular mechanism: ceRNA sponge mechanism (circRNA sponges miRNA to regulate target gene expression).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Prognosis-related ceRNA network identified for gastric cancer.
Description:

This study bioinformatically identified hsa_circ_0055521 as part of a prognosis-related ceRNA axis in gastric cancer, potentially sponging hsa-miR-204-5p to regulate FAP. The circRNA was inferred to be upregulated in tumor versus adjacent normal tissues based on the DEcircRNA pattern in the analyzed GEO dataset.
Confidence score:

0.1768
Other information
Title:

CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.

Journal: Discover oncology
Published: 2025
PubMed ID: 41417426
Study type:

bioinformatics study
Data availability: TCGA-STAD; GSE83521; GSE93415; GSE118916; https://www.proteinatlas.org
Code availability: -