| Expression pattern: |
UP |
| Associated gene: |
ABCC1 |
| Associated microRNA: |
miR-145 |
| Biological function: |
enhances cisplatin resistance (chemoresistance) in gastric cancer cells; reduces cisplatin-induced apoptosis |
| Molecular mechanism: |
Exosomal transfer of circTEX2 from M2 macrophages to gastric cancer cells; circTEX2 sponges miR-145 to upregulate ABCC1 |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; Agarose Gel Electrophoresis; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circTEX2 is enriched in M2 macrophages and their exosomes and is delivered to gastric cancer cells. It acts as a ceRNA sponge for miR-145, increasing ABCC1 expression and thereby promoting cisplatin resistance and reducing cisplatin-induced apoptosis; silencing circTEX2 or disrupting the miR-145/ABCC1 arm restores cisplatin sensitivity. |
| Confidence score: |
0.8331 |