| Expression pattern: |
DN |
| Associated gene: |
Smad4, DHX9 |
| Associated microRNA: |
miR-1285-5p |
| Biological function: |
Overexpression of hsa_circ_0001206 inhibited PCa cell proliferation, migration, and invasion in vitro and suppressed tumor growth in vivo. |
| Molecular mechanism: |
hsa_circ_0001206 may act as a miR-1285-5p sponge to regulate Smad4, and its downregulation is partly caused by DHX9. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Western Blot |
| Clinical significance: |
hsa_circ_0001206 had diagnostic value for PCa and was associated with Gleason score and pathological stage of patients with PCa. |
| Description: |
hsa_circ_0001206 is downregulated in prostate cancer tissues and cell lines and has potential diagnostic value. Functional assays indicate that restoring hsa_circ_0001206 suppresses PCa proliferation, migration, invasion, and xenograft tumor growth, likely through the hsa_circ_0001206/miR-1285-5p/Smad4 axis, while DHX9 contributes to its downregulation. |
| Confidence score: |
0.7357 |