circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_000543
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: target gene mRNAs
Associated microRNA: -
Biological function: Potential molecular biomarker for gastric cancer; no circRNA-specific cellular function was experimentally confirmed.
Molecular mechanism: Possible circRNA-miRNA-mRNA regulatory mechanism through miRNA adsorption and regulation of target gene mRNAs.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential new molecular biomarker for gastric cancer in the future.
Description:

hsa_circRNA_000543 was selected as an up-regulated circRNA from the microarray screen, but its qRT-PCR validation was not significant. Therefore, its gastric cancer association is supported only at low confidence, and no specific functional mechanism was experimentally demonstrated beyond the proposed circRNA-miRNA-mRNA regulatory model.
Confidence score:

0.5135
Other information
Title:

Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.

Journal: Oncology reports
Published: 2017
PubMed ID: 28184940
Study type:

combined bioinformatics and clinical sample validation study
Data availability: -
Code availability: -