circRNA basic information
circBase ID: hsa_circ_0002727
Name: -
Synonym: circRNA-0002727
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; adjacent normal tissues
Cell lines:

A549; PC-9; HCC827; SPC-A1; 16HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KIF14
Associated microRNA: miR-144-3p
Biological function: Promotes LUAD cell proliferation, migration and invasion; enhances malignant behaviors and progression/metastasis.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-144-3p, thereby increasing KIF14 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-0002727 is up-regulated in LUAD tissues and LUAD cell lines and functions as an oncogenic circRNA. It sponges miR-144-3p to increase KIF14 expression, thereby promoting proliferation, migration and invasion of LUAD cells.
Confidence score:

0.6528
Other information
Title:

Novel circular RNA circ-0002727 regulates miR-144-3p/KIF14 pathway to promote lung adenocarcinoma progression.

Journal: Frontiers in cell and developmental biology
Published: 2023
PubMed ID: 38033864
Study type:

combined biological and clinical study
Data availability: GSE101586; GSE101684; TCGA-LUAD; https://www.frontiersin.org/articles/10.3389/fcell.2023.1249174/full#supplementary-material
Code availability: -