circRNA basic information
circBase ID: hsa_circ_0004913
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:62248459-62265775:-
Genomic location(hg38): chr17:64171099-64188415:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

human HCC tissues; para-tumorous tissues
Cell lines:

Bel7402; HEK293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NUDT21, INPPL1
Associated microRNA: miR-184
Biological function: hsa_circ_0004913 antagonized miR-184-mediated silencing and restored INPPL1 expression in the ceRNA model.
Molecular mechanism: NUDT21 promotes hsa_circ_0004913 cyclization through UGUA motifs; hsa_circ_0004913 functions as a ceRNA sponge for miR-184 to relieve repression of INPPL1.
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
Q
B
S
M
Validation methods:

Microarray; RNA-seq; RT-qPCR; Northern Blot; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

hsa_circ_0004913 is a NUDT21 target circRNA selected as downregulated in HCC-related datasets and NUDT21-knockdown HCC cells. It participates in a ceRNA pathway by antagonizing miR-184-mediated silencing of INPPL1, and NUDT21 knockdown disrupts this circRNA-miRNA-mRNA crosstalk.
Confidence score:

0.5777
Other information
Title:

NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma.

Journal: Oncogene
Published: 2020
PubMed ID: 31570791
Study type:

combined bioinformatics and biological research
Data availability: GSE94508; GSE14520; Supplementary Table 1; Supplementary Table 2; Supplementary Table 3; Supplementary Table 4
Code availability: -