| Expression pattern: |
UP |
| Associated gene: |
WNT2B / Wnt family members 2B, Ago2 |
| Associated microRNA: |
miR-4529-5p |
| Biological function: |
Promotes proliferation and invasion, inhibits apoptosis, and promotes cell-cycle progression (increases G2/M phase) in gastric cancer cells. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) sponging miR-4529-5p to upregulate WNT2B. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot |
| Clinical significance: |
High expression is associated with unfavorable prognosis (worse overall survival) in GC patients, but authors note limited sample size and lack of further verification. |
| Description: |
hsa_circRNA_102415 is up-regulated in gastric cancer tissues/cell lines and promotes malignant phenotypes (proliferation, invasion, cell-cycle progression) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-4529-5p to increase WNT2B expression, and higher expression is associated with worse survival in the studied cohort. |
| Confidence score: |
0.7941 |