| Expression pattern: |
DN |
| Associated gene: |
MIER3, NEURL1B, LITAF, PRKAA2, GNG12, CCNYL1, LIFR, SEMA6A, TGFBR3, PHLPP2, MAP1B, THRB, SLC20A1 |
| Associated microRNA: |
miR-27a-3p, miR-379-5p |
| Biological function: |
inhibits CRC cells proliferation |
| Molecular mechanism: |
ceRNA network (miRNA sponge) involving miR-27a-3p and miR-379-5p regulating downstream mRNAs |
| Biological pathway or process: |
proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Transfection; CCK8; Colony Formation Assay; EdU Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Downregulated in CRC and negatively associated with distant metastasis; higher expression indicates better survival/prognosis in CRC patients; potential prognostic and immunotherapeutic biomarker. |
| Description: |
This study identified hsa_circ_0066351 (from FLNB) as significantly down-regulated in colorectal cancer tissues and cell lines. Functional assays showed it suppresses CRC cell proliferation. Bioinformatic ceRNA analysis proposed a hsa_circ_0066351-miR-27a-3p/miR-379-5p-mRNA network with prognostic and potential immunotherapy-related relevance. |
| Confidence score: |
0.7713 |