circRNA basic information
circBase ID: hsa_circ_0023984
Name: hsa_circ_NOX4
Synonym: circRNA_100933
Host Gene: NOX4
Genomic location(hg19): chr11:89133184-89135710:-
Genomic location(hg38): chr11:89400016-89402542:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005005
MONDO name: clear cell renal carcinoma
Disease details: clear cell renal cell carcinoma
Disease DO ID:
 4467
Disease MeSH ID:
 -
Disease NCIt ID:
 C4033
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ccRCC tumor tissue; adjacent normal renal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker (moderate discrimination of tumor vs adjacent normal); not correlated with cancer-specific survival.
Molecular mechanism: In-silico circRNA-miRNA-gene interaction analysis performed, but specific functional interactions were not experimentally validated.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Differentially expressed in tumor vs adjacent normal tissue and shows discriminative ability by ROC; not correlated with cancer-specific survival.
Description:

CircNOX4 is down-regulated in ccRCC tumor tissue versus adjacent normal tissue and shows diagnostic discrimination by ROC analysis. However, its expression is not associated with cancer-specific survival in this cohort.
Confidence score:

0.7278
Other information
Title:

Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy.

Journal: Cancers
Published: 2019
PubMed ID: 31575051
Study type:

combined biological and clinical study
Data availability: TCGA-KIRC; Supplemental Microarray Excel File
Code availability: -