| Expression pattern: |
DN |
| Associated gene: |
NAT10, YAP mRNA, YAP |
| Associated microRNA: |
- |
| Biological function: |
Inhibits tumor growth and lymph node metastasis; suppresses proliferation, migration and invasion of cervical cancer cells. |
| Molecular mechanism: |
circMAST1 directly binds/sequesters NAT10, blocks NAT10 binding to YAP mRNA, reduces NAT10-mediated ac4C modification of YAP mRNA, decreases YAP mRNA stability and promotes degradation, thereby suppressing CCa progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); mRNA stability (inhibits); m6A modification (other); Hippo/YAP (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; RNA-seq; Western Blot; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; IHC (Immunohistochemistry); IF (Immunofluorescence); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
Low circMAST1 expression was correlated with poor prognosis/overall survival and with tumor size and lymph node metastasis in CCa patients. |
| Description: |
circMAST1 is down-regulated in cervical cancer and acts as a tumor suppressor. It binds and sequesters NAT10, reducing NAT10-mediated ac4C modification of YAP mRNA, which decreases YAP mRNA stability and inhibits tumor growth and lymph node metastasis. |
| Confidence score: |
0.8861 |