circRNA basic information
circBase ID: hsa_circ_0061274
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr21:16386664-16386787:-
Genomic location(hg38): chr21:15014343-15014466:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

platelets; plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Acts as a platelet-derived circulating biomarker to discriminate LUAD from healthy donors and benign pulmonary nodules, including stage I disease.
Molecular mechanism: Not experimentally addressed; mechanistic role remains unknown.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Platelet hsa_circ_0061274 distinguishes LUAD from healthy donors and benign pulmonary nodules with ROC AUCs reported, including stage I LUAD vs BPN.
Description:

This study identified platelet hsa_circ_0061274 as significantly down-regulated in LUAD and validated it by RT-qPCR in independent cohorts. It showed diagnostic utility for distinguishing LUAD from healthy donors and benign pulmonary nodules (including stage I disease), but no functional mechanism was experimentally established.
Confidence score:

0.5963
Other information
Title:

Comprehensive circRNA profiling of platelets and exosomes identifies hsa_circ_0061274 as a novel biomarker for lung adenocarcinoma.

Journal: Frontiers in immunology
Published: 2026
PubMed ID: 41929494
Study type:

combined biological and clinical study
Data availability: PRJCA052366
Code availability: -