| Expression pattern: |
UP |
| Associated gene: |
HOXC11, CCL5 |
| Associated microRNA: |
miR-1225-3p |
| Biological function: |
May contribute to breast cancer development and be associated with response to NAT through a proposed ceRNA axis affecting HOXC11 and CCL5. |
| Molecular mechanism: |
ceRNA mechanism: circRNA_42276 (with MIAT) may sponge miR-1225-3p to regulate HOXC11 and downstream CCL5 expression. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Candidate biomarker for response to neoadjuvant therapy (NAT) in breast cancer. |
| Description: |
circRNA_42276 is upregulated in pre-therapy breast cancer tumor tissues versus adjacent normal tissues and decreases after NAT. It is proposed to function in a ceRNA axis (circRNA_42276/MIAT-miR-1225-3p-HOXC11-CCL5), suggesting relevance to tumor biology and NAT responsiveness. |
| Confidence score: |
0.4032 |