circRNA basic information
circBase ID: hsa_circ_0050119
Name: hsa_circ_FKBP8
Synonym: circFKBP8(5S,6)
Host Gene: FKBP8
Genomic location(hg19): chr19:18648410-18649243:-
Genomic location(hg38): chr19:18537600-18538433:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson’s disease / PD
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SH-SY5Y
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: alpha-synuclein
Associated microRNA: -
Biological function: promotes alpha-synuclein accumulation/expression in an in vitro PD (MPP⁺-treated) SH-SY5Y cell model
Molecular mechanism: circRNA-encoded protein (cFKBP8) positively regulates alpha-synuclein expression; downstream pathway unknown
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Western Blot
Clinical significance:

potential candidate biomarker and therapeutic target in PD (based on cellular model)
Description:

In MPP⁺-treated SH-SY5Y cells (an in vitro PD model), circFKBP8(5S,6) is up-regulated. Manipulating its encoded protein cFKBP8 bidirectionally changes alpha-synuclein levels, supporting a positive regulatory role on alpha-synuclein expression/accumulation, while downstream pathways remain undefined.
Confidence score:

0.3513
Other information
Title:

circFKBP8(5S,6)-encoded protein modulates alpha-synuclein expression in SH-SY5Y cells.

Journal: Molecular biology reports
Published: 2026
PubMed ID: 41925956
Study type:

biological research
Data availability: 10.1007/s11033-026-11723-z
Code availability: -