| Expression pattern: |
DN |
| Associated gene: |
NF2, VEGF, PAK1 |
| Associated microRNA: |
miRNA-146a |
| Biological function: |
May act as a serum biomarker in PCOS and is implicated in hormonal imbalance/steroidogenesis-related dysregulation; proposed to sponge miRNA-146a. |
| Molecular mechanism: |
Proposed circRNA sponge (ceRNA-like) mechanism in which reduced circRNA Pum1_0014 fails to sponge miRNA-146a, increasing free miRNA-146a and enhancing repression of downstream target mRNAs (e.g., NF2/VEGF/PAK1 components). |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circRNA Pum1_0014 could potentially serve as a non-invasive serum biomarker for early PCOS detection (AUC 0.939; sensitivity 88%; specificity 100%). |
| Description: |
Serum circRNA Pum1_0014 is significantly decreased in women with PCOS and shows diagnostic value for early PCOS detection. The study proposes that circRNA Pum1_0014 may sponge miRNA-146a, linking this axis to hormonal/steroidogenesis-related imbalance in PCOS. |
| Confidence score: |
0.6238 |