| Expression pattern: |
UP |
| Associated gene: |
CXCL3, AGO2, MET |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
Promotes NSCLC cell proliferation, metastasis (migration/invasion), and immune evasion. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-145-5p, thereby upregulating CXCL3; associated with reduced CD8+ T-cell infiltration (immune escape). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); immune regulation (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Cohort Study; Survival Analysis; circRIP; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
High circMET expression correlates with aggressive clinicopathological features and is an independent risk factor for short OS and PFS; proposed diagnostic and prognostic biomarker in NSCLC. |
| Description: |
circMET is up-regulated in NSCLC tissues and promotes malignant phenotypes (proliferation, migration/invasion/metastasis) and immune evasion. It functions mainly as a ceRNA by sponging miR-145-5p to relieve repression of CXCL3, and high circMET predicts worse OS/PFS. |
| Confidence score: |
0.861 |