circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: CDR1as(1) / CiRS7
Host Gene: CDR1
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060134
MONDO name: atherosclerotic cardiovascular disease
Disease details: carotid atherosclerotic plaque
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C35771
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs); plaque tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDR1
Associated microRNA: hsa-miR-7
Biological function: Biomarker for plaque vulnerability; strongest discriminatory capacity among tested circRNAs; associated with plaque inflammatory status via correlation of circRNA_SCORE with in-plaque_SCORE.
Molecular mechanism: Acts as an miRNA sponge (hsa-miR-7) per discussion; additionally analyzed in predicted ceRNA network and KEGG enrichment (hypothesis-generating).
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

CDR1as(1) and CDR1as(1)/CDR1 mRNA ratio show strongest ROC discrimination for vulnerable vs stable plaques; suggested as noninvasive biomarker.
Description:

CDR1as(1) is strongly up-regulated in PBMCs from patients with vulnerable carotid plaques and provides the best ROC-based discrimination among tested circRNAs, supporting its biomarker potential. The paper discusses CDR1as as a hsa-miR-7 sponge and includes it in a hypothesis-generating ceRNA/pathway enrichment analysis.
Confidence score:

0.459
Other information
Title:

Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability.

Journal: Non-coding RNA research
Published: 2026
PubMed ID: 41809636
Study type:

combined biological and clinical study
Data availability: The raw data supporting the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -