circRNA basic information
circBase ID: hsa_circ_0008732
Name: hsa_circ_BNC2
Synonym: -
Host Gene: BNC2
Genomic location(hg19): chr9:16727794-16738483:-
Genomic location(hg38): chr9:16727796-16738485:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005140
MONDO name: ovarian carcinoma
Disease details: epithelial ovarian cancer
Disease DO ID:
 4001
Disease MeSH ID:
 -
Disease NCIt ID:
 C4908
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for EOC; lower plasma levels associated with adverse clinicopathologic features (higher grade, LNM, distant metastasis).
Molecular mechanism: Not established in this study.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circBNC2 differentiates EOC from benign ovarian cyst and healthy controls with high ROC AUC; useful for early-stage EOC discrimination.
Description:

Plasma circBNC2 (hsa_circ_0008732, from host gene BNC2) is down-regulated in epithelial ovarian cancer and shows high diagnostic performance (ROC AUC ~0.88-0.92) versus benign ovarian cysts and healthy controls, including early-stage EOC. Lower circBNC2 levels are associated with more aggressive clinicopathologic features such as higher grade, lymph node metastasis, and distant metastasis.
Confidence score:

0.4187
Other information
Title:

Utility Of Plasma circBNC2 As A Diagnostic Biomarker In Epithelial Ovarian Cancer.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 32009804
Study type:

clinical study
Data availability: -
Code availability: -