| Expression pattern: |
DN |
| Associated gene: |
S100A9 |
| Associated microRNA: |
- |
| Biological function: |
inhibits migration and invasion (metastasis) of prostate cancer cells |
| Molecular mechanism: |
circ_0006156 binds to S100A9 and stabilizes S100A9 protein by blocking its ubiquitination |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); ubiquitination (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; RNA Pull-Down; Co-IP; RIP (RNA Immunoprecipitation); Western Blot; Mass spectrometry analysis; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0006156 is down-regulated in prostate cancer tissues and cell lines and suppresses migration/invasion and metastasis. It directly binds S100A9 and increases S100A9 protein stability by reducing S100A9 ubiquitination, thereby inhibiting malignant progression in vitro and in vivo. |
| Confidence score: |
0.8517 |