circRNA basic information
circBase ID: -
Name: hsa_circ_FBXL5
Synonym: -
Host Gene: FBXL5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Prognostic association in p53C molecular subtype (reported as poorer survival with high expression, though another analysis notes no significant association).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

High expression was reported to be associated with poorer survival in the p53C molecular subtype.
Description:

This circRNA (FBXL5-derived; 4__15625252__15644657) was identified via RNA-seq as a subtype-associated prognostic circRNA in AML, reported to relate to poorer survival in the p53C subgroup, but the manuscript also notes lack of significant association in a supplementary analysis, making the prognostic direction uncertain overall.
Confidence score:

0.348
Other information
Title:

Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.

Journal: NPJ precision oncology
Published: 2026
PubMed ID: 41787043
Study type:

combined biological and clinical study
Data availability: phs001657.v1.p1; GSE158596; https://zenodo.org/records/7274740; 10.5281/zenodo.292986
Code availability: -