circRNA basic information
circBase ID: hsa_circ_0084678
Name: hsa_circ_CSPP1
Synonym: -
Host Gene: CSPP1
Genomic location(hg19): chr8:68030482-68049838:+
Genomic location(hg38): chr8:67118247-67137603:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with improved overall survival; associated with improved responses to several drugs (including Lenalidomide).
Molecular mechanism: -
Biological pathway or process:

drug resistance (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

High expression is associated with significantly improved overall survival; Lenalidomide sensitivity association validated in Beat-AML and FIMM-AML.
Description:

In AML, hsa_circ_0084678 (CSPP1-derived) is higher in AML than healthy HSPCs and higher expression is linked to better overall survival (independent of host gene after adjustment). Its expression stratifies patients with improved sensitivity to multiple drugs, including Lenalidomide, validated across Beat-AML and FIMM-AML datasets.
Confidence score:

0.348
Other information
Title:

Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.

Journal: NPJ precision oncology
Published: 2026
PubMed ID: 41787043
Study type:

combined biological and clinical study
Data availability: phs001657.v1.p1; GSE158596; https://zenodo.org/records/7274740; 10.5281/zenodo.292986
Code availability: -