circRNA basic information
circBase ID: hsa_circ_0067934
Name: -
Synonym: circ_0067934
Host Gene: -
Genomic location(hg19): chr3:170013698-170015181:+
Genomic location(hg38): chr3:170295910-170297393:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues; tumor and non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic and prognostic biomarker for HCC; expression positively correlated with tumor size, TNM stage and microvascular invasion.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

circ_0067934 had favorable specificity and sensitivity for distinguishing HCC, with AUC 0.8412, and upregulation was associated with unfavorable prognosis.
Description:

This clinical study found that circ_0067934 is significantly up-regulated in HCC tissues compared with adjacent non-tumor tissues. Higher circ_0067934 expression correlated with tumor size, TNM stage, microvascular invasion, diagnostic performance by ROC analysis, and poorer prognosis, supporting its potential value as a diagnostic and prognostic biomarker for HCC.
Confidence score:

0.4992
Other information
Title:

circ_0067934: A Potential Biomarker and Therapeutic Target for Hepatocellular Carcinoma.

Journal: Annals of clinical and laboratory science
Published: 2020
PubMed ID: 33334787
Study type:

clinical study
Data availability: -
Code availability: -