| Expression pattern: |
UP |
| Associated gene: |
GPR133 |
| Associated microRNA: |
miR-106a-5p |
| Biological function: |
Promotes glioma cell proliferation, migration, invasion and EMT, and promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-106a-5p to increase GPR133 expression (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circNRIP1 expression correlated with reduced overall survival in glioma patients. |
| Description: |
circNRIP1 is up-regulated in glioma tissues and cell lines and is associated with poorer overall survival. It promotes glioma malignant phenotypes (proliferation, migration, invasion, EMT) and tumor growth by sponging miR-106a-5p to upregulate GPR133 (circNRIP1/miR-106a-5p/GPR133 axis). |
| Confidence score: |
0.7408 |