| Expression pattern: |
UP |
| Associated gene: |
KRAS |
| Associated microRNA: |
miR-101-3p |
| Biological function: |
promotes proliferation, cell cycle progression, and aerobic glycolysis; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circ-MEMO1 acts as a miRNA sponge for miR-101-3p to up-regulate KRAS, promoting glycolysis-related enzymes (HK2, LDHA) and malignant phenotypes |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circ-MEMO1 predicted poor prognosis in NSCLC patients; serum exosomal circ-MEMO1 (exo-circ-MEMO1) may be a diagnostic marker (ROC AUC ~0.76). |
| Description: |
circ-MEMO1 is up-regulated in NSCLC tissues and serum exosomes and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes NSCLC cell proliferation, cell-cycle progression, and aerobic glycolysis while inhibiting apoptosis, largely via the circ-MEMO1/miR-101-3p/KRAS ceRNA axis. High circ-MEMO1 correlates with poor survival and exosomal circ-MEMO1 shows diagnostic potential by ROC analysis. |
| Confidence score: |
0.8709 |