circRNA basic information
circBase ID: hsa_circ_0018064
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:29801663-29820217:-
Genomic location(hg38): chr10:29512734-29531288:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: oesophageal squamous cell carcinoma / ESCC
Disease DO ID:
3748
Disease MeSH ID:
C562729; D000077277
Disease NCIt ID:
C4024
Disease ICD11 ID:
1417891145
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tissues; adjacent non-cancer tissues

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DS
Associated gene: 197 target genes
Associated microRNA: hsa-miR-497-5p, hsa-miR-195-5p, hsa-miR-4661-5p, hsa-miR-450b-5p, hsa-miR-1269a, hsa-miR-338-3p, hsa-miR-424-5p
Biological function: May act as a ceRNA in an ESCC circRNA-miRNA-mRNA coexpression network.
Molecular mechanism: Predicted ceRNA mechanism within a circRNA-miRNA-mRNA network.
Biological pathway or process:

ceRNA regulation (other)

Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis

Clinical significance:

-

Description:

hsa_circ_0018064 was identified as one of five dysregulated circRNAs included in the ESCC circRNA-miRNA-mRNA ceRNA network. The paper supports its disease association through circRNA sequencing, qRT-PCR validation of selected circRNAs and bioinformatic network construction, but does not provide individual mechanistic experiments for this circRNA.

Confidence score:

0.4685

Other information
Title:

RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma.

Journal: Carcinogenesis
Published: 2023
PubMed ID: 37402652
Study type:

combined bioinformatics and clinical study

Data availability: The data underlying this article will be shared on reasonable request to the corresponding author; TCGA
Code availability: -