| Expression pattern: |
DN |
| Associated gene: |
TCF7L2, NRAS, CTNNB1, KRAS, SMAD4, HIF1A, CDKN1B, CDK6, FOXO3 |
| Associated microRNA: |
hsa-miR-1179, hsa-miR-1303, hsa-miR-217, hsa-miR-450b-3p, hsa-miR-769-3p, hsa-miR-512-5p, hsa-miR-513a-5p, hsa-miR-661, hsa-miR-665, hsa-miR-767-5 |
| Biological function: |
May be involved in AIS pathogenesis and reflects disease severity (lower levels associated with more severe injury and longer infarct time); potential diagnostic biomarker. |
| Molecular mechanism: |
Bioinformatically predicted ceRNA network involving miRNA binding and downstream target genes; PPI core proteins identified from predicted target genes. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other); proliferation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Plasma hsa_circ_0004099 shows diagnostic value for AIS (AUC 0.923) and correlates negatively with NIHSS severity score and infarct time. |
| Description: |
hsa_circ_0004099 is down-regulated in AIS patient plasma and its lower level is associated with higher NIHSS severity and longer infarct time. It shows strong diagnostic potential for AIS (ROC AUC 0.923). Bioinformatic analyses predict a ceRNA network with 10 candidate miRNAs and downstream targets enriched in apoptosis/transcriptional regulation and cancer-related/proliferation-associated genes. |
| Confidence score: |
0.5534 |