| Expression pattern: |
UP |
| Associated gene: |
YBX1, IGF2BP1, hnRNP C1/C2, hnRNP K |
| Associated microRNA: |
- |
| Biological function: |
Promotes oncogenesis by increasing proliferation, colony formation, migration and invasion; affects sorafenib sensitivity in a cell-type-specific manner. |
| Molecular mechanism: |
Binds RNA-binding proteins (notably YBX1); transcriptome perturbation suggests downstream transcription factor and pathway modulation. |
| Biological pathway or process: |
proliferation (promotes); migration (other); invasion (promotes); MAPK (other); PI3K/AKT (other); TGF-beta/SMAD (other); apoptosis (other); cell cycle (promotes); drug resistance (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; RNA Pull-Down; Western Blot; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; EdU Staining; IF (Immunofluorescence); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0062682 is up-regulated in HCC and promotes oncogenic phenotypes in HCC cell models, including proliferation, colony formation, migration and invasion, with cell-type-specific effects on migration and sorafenib response. Mechanistically, it binds multiple RBPs, with YBX1 validated as a key binding partner, and its perturbation induces broad transcriptomic and pathway changes linked to oncogenesis. |
| Confidence score: |
0.7736 |