| Expression pattern: |
UP |
| Associated gene: |
STAT1 |
| Associated microRNA: |
miR-1296-5p |
| Biological function: |
Promotes luminal breast cancer progression, increases proliferation, inhibits apoptosis, and contributes to tamoxifen resistance. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1296-5p to de-repress STAT1 (ceRNA mechanism), thereby promoting malignant phenotypes and tamoxifen resistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNA-seq; Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Survival Analysis; ROC Analysis |
| Clinical significance: |
High hsa_circ_0086735 was associated with poor overall survival and poor distant metastasis-free survival (DMFS) in luminal breast cancer patients treated with tamoxifen. |
| Description: |
In luminal-subtype breast cancer, hsa_circ_0086735 is upregulated and functions as a ceRNA that sponges miR-1296-5p to increase STAT1 expression. This axis promotes proliferation, inhibits apoptosis, contributes to tamoxifen resistance, and high hsa_circ_0086735 predicts worse OS and DMFS. |
| Confidence score: |
0.8347 |