circRNA basic information
circBase ID: -
Name: hsa_circ_CD151
Synonym: circCD151
Host Gene: CD151
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissues; adjacent normal tissues
Cell lines:

A549; NCI-H292; BEAS-2B; NCI-H460; 95-D
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GLI2
Associated microRNA: miR-30d-5p
Biological function: promotes proliferation; promotes invasion; promotes stemness
Molecular mechanism: ceRNA mechanism: circCD151 sponges miR-30d-5p to upregulate GLI2 expression
Biological pathway or process:

proliferation (promotes); invasion (promotes); stemness (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

circCD151 may serve the role of oncogene in lung cancer and is a potential tumor marker.
Description:

circCD151 is up-regulated in NSCLC/lung adenocarcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes lung cancer cell proliferation, invasion and stemness via a ceRNA axis in which circCD151 sponges miR-30d-5p to increase GLI2 expression.
Confidence score:

0.6777
Other information
Title:

circCD151 promotes GLI2 expression by regulating miR‑30d‑5p and enhancing proliferation, invasion and stemness of lung cancer.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 34368867
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed in the current study are available from the corresponding author on reasonable request.
Code availability: -