| Expression pattern: |
UP |
| Associated gene: |
GLI2 |
| Associated microRNA: |
miR-30d-5p |
| Biological function: |
promotes proliferation; promotes invasion; promotes stemness |
| Molecular mechanism: |
ceRNA mechanism: circCD151 sponges miR-30d-5p to upregulate GLI2 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circCD151 may serve the role of oncogene in lung cancer and is a potential tumor marker. |
| Description: |
circCD151 is up-regulated in NSCLC/lung adenocarcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes lung cancer cell proliferation, invasion and stemness via a ceRNA axis in which circCD151 sponges miR-30d-5p to increase GLI2 expression. |
| Confidence score: |
0.6777 |