| Expression pattern: |
UP |
| Associated gene: |
STAT3, p-STAT3, lnc865, lnc556 |
| Associated microRNA: |
miR-29b-2-5p |
| Biological function: |
Promotes pulmonary fibrosis by participating in a regulatory RNA network centered on miR-29b-2-5p and STAT3 phosphorylation. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA for miR-29b-2-5p, influencing STAT3 phosphorylation within an ncRNA network. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); fibrosis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; IF (Immunofluorescence); Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
In bleomycin-induced mouse pulmonary fibrosis, circ057 is up-regulated and predominantly localized in the cytoplasm. It directly binds miR-29b-2-5p and participates in an ncRNA regulatory network that modulates STAT3 phosphorylation to promote fibrotic progression. |
| Confidence score: |
0.7753 |