| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0005075 promotes proliferation and invasion of colorectal cancer cells and is associated with distal metastasis, invasion, TNM stage, tumor diameter, and poor overall survival. |
| Molecular mechanism: |
The study did not define a specific molecular mechanism; functional effects were assessed by overexpression and knockdown of hsa_circ_0005075 in CRC cells. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Cohort Study; Survival Analysis |
| Clinical significance: |
hsa_circ_0005075 may serve as a promising diagnostic marker, therapy target, and prognostic indicator in colorectal cancer; high expression is associated with clinicopathological parameters and poorer survival. |
| Description: |
hsa_circ_0005075 is up-regulated in colorectal cancer tissues, plasma, and CRC cell lines. Its high expression correlates with advanced clinicopathological features and poor overall survival, and functional assays show that it promotes CRC cell proliferation and invasion. The study supports hsa_circ_0005075 as a potential diagnostic marker and therapeutic target for colorectal cancer, although a specific downstream molecular axis was not defined. |
| Confidence score: |
0.6419 |