| Expression pattern: |
UP |
| Associated gene: |
ERK, p‐ERK, P38, p‐P38, JNK, p‐JNK |
| Associated microRNA: |
miR‐1184, miR‐608, miR‐6737‐5p, miR‐6742‐5p, miR‐6768‐5p, miR‐6812‐5p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by binding (sponging) miR-608 to activate the MAPK signaling pathway (reduced p-ERK/p-P38/p-JNK upon knockdown). |
| Biological pathway or process: |
MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
High hsa‐circ‐0052001 expression is associated with clinicopathological characteristics and predicts worse prognosis/shorter OS, especially in advanced (TNM III-IV) gastric cancer. |
| Description: |
hsa-circ-0052001 is up-regulated in gastric cancer tissues/cells and promotes proliferation, migration/invasion and tumor growth. It functions in part by sponging miR-608 and activating MAPK signaling (ERK/P38/JNK phosphorylation). High expression is associated with worse overall survival, particularly in advanced-stage patients. |
| Confidence score: |
0.6778 |