| Expression pattern: |
UP |
| Associated gene: |
RBM15, EIF4A3, JAK2, STAT3, STAT5 |
| Associated microRNA: |
- |
| Biological function: |
Promotes ovarian cancer cell proliferation, colony formation, migration, invasion, PD-L1-mediated immune escape, and tumor progression; reduces CD8 + T cell activity and anti-tumor cytokine secretion and enhances CD8 + T cell apoptosis. |
| Molecular mechanism: |
RBM15 upregulates circFGFR3 through m6A modification; circFGFR3 binds to EIF4A3 and enhances JAK2, STAT3, and STAT5 mRNA stability, activating the JAK/STAT signaling pathway and promoting PD-L1-mediated immune evasion. |
| Biological pathway or process: |
JAK/STAT (promotes); immune regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); mRNA stability (promotes); m6A modification (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; MeRIP / MeRIP-seq; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circFGFR3 is upregulated in ovarian cancer cells and acts as a pro-tumor and pro-immune-escape circRNA. RBM15 increases circFGFR3 expression via m6A modification, while circFGFR3 recruits EIF4A3 to stabilize JAK2, STAT3, and STAT5 mRNAs, activating JAK/STAT signaling and increasing PD-L1-mediated immune evasion. |
| Confidence score: |
0.8119 |