| Expression pattern: |
DN |
| Associated gene: |
PCBP2 |
| Associated microRNA: |
- |
| Biological function: |
Associated with RA disease activity; binds PCBP2 in T cells (functional consequence not defined). |
| Molecular mechanism: |
Protein-binding (circ-UBXN7-PCBP2 interaction). |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; RNA Pull-Down; Western Blot; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ-UBXN7 expression was inversely associated with RA disease activity (DAS28-ESR). |
| Description: |
circ-UBXN7 is down-regulated in RA T cells and its expression is inversely associated with RA disease activity (DAS28-ESR). It physically binds the RNA-binding protein PCBP2, suggesting a protein-binding regulatory role in T cells. |
| Confidence score: |
0.7164 |