circRNA basic information
circBase ID: -
Name: hsa_circ_ASCC3
Synonym: circASCC3-1
Host Gene: ASCC3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005005
MONDO name: clear cell renal carcinoma
Disease details: clear cell renal cell carcinoma / ccRCC
Disease DO ID:
 4467
Disease MeSH ID:
 -
Disease NCIt ID:
 C4033
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: HNRNPD
Associated microRNA: -
Biological function: not specified
Molecular mechanism: HNRNPD physically associates with circASCC3-1 (pulldown and RIP) and HNRNPD depletion increases its FISH signal, consistent with an inhibitory role of HNRNPD on circRNA biogenesis; no disease-specific function was established.
Biological pathway or process:

not specified
Detected method:
H
Validation methods:

FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation)
Clinical significance:

-
Description:

circASCC3-1 (circASCC3-1) was used as an example circRNA showing increased FISH signal upon HNRNPD knockout and direct association with HNRNPD by pulldown and RIP, supporting an HNRNPD-mediated inhibitory regulation of circRNA biogenesis.
Confidence score:

0.385
Other information
Title:

HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.

Journal: RNA biology
Published: 2024
PubMed ID: 39180763
Study type:

biological research
Data availability: GSE212767; GSE240942
Code availability: -