circRNA basic information
circBase ID: hsa_circ_0005583
Name: hsa_circ_ATM
Synonym: -
Host Gene: ATM
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005252
MONDO name: heart failure
Disease details: Heart failure with preserved ejection fraction
Disease DO ID:
 -
Disease MeSH ID:
 D006333
Disease NCIt ID:
 C50577
Disease ICD11 ID:
 1458683894
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

epicardial adipose tissue / EAT
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: No direct biological function was experimentally validated in this study; hsa_circ_0005583 was identified as a differentially expressed EAT circRNA and linked by host-gene annotation to ATM, which is associated with cell cycle control and DNA repair.
Molecular mechanism: Host-gene annotation suggests association with ATM-related cell cycle control and DNA repair; no circRNA-specific molecular mechanism was experimentally demonstrated.
Biological pathway or process:

cell cycle (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May provide insight into diagnostic markers and therapeutic targets in the context of HFpEF.
Description:

hsa_circ_0005583 was identified from EAT circRNA profiling in HFpEF and was annotated to the ATM gene locus. The study did not validate its expression by qRT-PCR or experimentally test its function.
Confidence score:

0.348
Other information
Title:

Genome-wide screening for circRNAs in epicardial adipose tissue of heart failure patients with preserved ejection fraction.

Journal: American journal of translational research
Published: 2023
PubMed ID: 37560213
Study type:

combined clinical and bioinformatics study
Data availability: Supplementary File
Code availability: -