| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for ovarian cancer; associated with epithelial cell proliferation and migration (regulatory network suggested). |
| Molecular mechanism: |
Suggested ceRNA-like role as a miRNA adsorption sponge forming a circRNA-miRNA-mRNA regulatory network. |
| Biological pathway or process: |
proliferation (other); migration (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circMUC16 detected by DCMC-CRISPR distinguished ovarian cancer patients from healthy controls with AUC 0.979 and specificity 100% in this cohort, suggesting potential early diagnostic biomarker utility. |
| Description: |
This study identified circMUC16 (hsa_circ_0049101) as an up-regulated circRNA in ovarian cancer and validated its specific expression in OC cell lines and patient peripheral blood. circMUC16 was suggested to act as a miRNA sponge within a circRNA-miRNA-mRNA network linked to proliferation and migration, and showed strong diagnostic performance when quantified by the DCMC-CRISPR assay. |
| Confidence score: |
0.559 |