| Expression pattern: |
DN |
| Associated gene: |
LIFR, 2447 mRNA-encoding genes |
| Associated microRNA: |
miR-1234-3p, miR-375-3p |
| Biological function: |
Potential ceRNA implicated in SCLC biology; functional validation required. |
| Molecular mechanism: |
Predicted miRNA sponging (ceRNA network) with downstream mRNA targets. |
| Biological pathway or process: |
MAPK (other); p53 signaling (other); cell cycle (other); autophagy (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic biomarker with AUC 0.9177 in SCLC. |
| Description: |
circLIFR is significantly down-regulated in SCLC tissues and forms a predicted ceRNA network with 26 interacting miRNAs and 2,447 downstream mRNA targets. It shows strong diagnostic performance (AUC 0.9177), but its mechanistic interactions are computationally predicted and require functional validation. |
| Confidence score: |
0.6895 |