| Expression pattern: |
UP |
| Associated gene: |
RRM2 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
Oncogenic in cervical cancer cells: promotes cell growth (viability/proliferation), migration and invasion, and inhibits apoptosis; mediates oxymatrine anti-tumor effects. |
| Molecular mechanism: |
ceRNA mechanism: circ_0008460 sponges miR-197-3p to relieve repression of RRM2, promoting malignant behaviors; oxymatrine downregulates circ_0008460 to activate miR-197-3p and suppress RRM2. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Clinical Sample Validation; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0008460 expression was associated with tumor size and lymph-node metastasis in CC patients. |
| Description: |
circ_0008460 is upregulated in cervical cancer tissues/cells and functions pro-tumor by promoting proliferation, migration and invasion and suppressing apoptosis. Mechanistically, it sponges miR-197-3p to increase RRM2 expression; oxymatrine inhibits CC partly by downregulating circ_0008460 and thereby activating the miR-197-3p/RRM2 axis. |
| Confidence score: |
0.7858 |