circRNA basic information
circBase ID: -
Name: hsa_circ_CSNK1G3
Synonym: circCSNK1G3
Host Gene: CSNK1G3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; paired surrounding normal brain tissues; A172 xenograft tumor tissues
Cell lines:

HCN-1a; A172; U251MG; U251; Pri-1; Pri-2; primary human astrocytes; HEK-293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CBX7, CDK1, CDC25A, caspase-3, caspase-9, PARP
Associated microRNA: miR-181d
Biological function: Promotes glioma cell viability, survival, proliferation, colony formation, migration, invasion and xenograft tumor growth; inhibits apoptosis through miR-181d stabilization and CBX7 downregulation.
Molecular mechanism: circCSNK1G3 directly interacts with and stabilizes miR-181d, leading to downregulation of the tumor-suppressor gene/protein CBX7; circCSNK1G3 silencing decreases miR-181d, increases CBX7, reduces CDK1 and CDC25A, and activates apoptotic markers.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); mitochondrial function (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Transwell Assay; TUNEL; ELISA; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for glioma treatment
Description:

circCSNK1G3 is upregulated in human glioma tissues and glioma cell lines and acts as an oncogenic circRNA. It promotes glioma cell survival, proliferation, migration, invasion and xenograft tumor growth by stabilizing miR-181d and suppressing the tumor-suppressor CBX7. Knockdown of circCSNK1G3 reduces miR-181d, increases CBX7, inhibits tumor growth and activates apoptosis, supporting circCSNK1G3 as a potential therapeutic target.
Confidence score:

0.612
Other information
Title:

A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.

Journal: International journal of biological macromolecules
Published: 2024
PubMed ID: 39033888
Study type:

combined biological and clinical study
Data availability: The original contributions presented in the study are included in the article/supplementary material.
Code availability: -