| Expression pattern: |
DN |
| Associated gene: |
CDH5, ANGPT2, DLL4, CLDN5, ANGPTL4, EDN1, HEY1, GATA2, CLEC14A, ADM |
| Associated microRNA: |
has-miR-424-5p, has-miR-503-5p, has-miR-331-3p, has-miR-17-3p |
| Biological function: |
May play a regulatory role in PAH development and is associated with endothelial cell proliferation and migration-related processes. |
| Molecular mechanism: |
Predicted ceRNA network (circRNA-miRNA-mRNA) involving hsa_circ_0005623 with PAH-related miRNAs and hub mRNAs. |
| Biological pathway or process: |
proliferation (other); migration (other); angiogenesis (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circ_0005623 expression levels in the plasma of PAH-CHD patients were associated with higher mPAP and showed diagnostic capability (ROC AUC 0.805). |
| Description: |
hsa_circ_0005623 (from SLC7A6) is significantly down-regulated in PAH-CHD, including in patient plasma and hypoxia-induced hPAECs. Its low plasma level correlates negatively with mPAP and shows diagnostic potential (AUC 0.805). Bioinformatic prediction suggests a circRNA-miRNA-mRNA ceRNA network involving miR-424-5p/miR-503-5p/miR-331-3p/miR-17-3p and endothelial-function-related hub genes. |
| Confidence score: |
0.5963 |