circRNA basic information
circBase ID: -
Name: hsa_circ_ASPH
Synonym: circASPH(2,3).1
Host Gene: AC090094
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: COVID-19 / Coronavirus disease 2019
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Time-dependent direction-flipping between COVID-19 non-survivors and survivors and linked to immune-correlated miRNA changes (computational).
Molecular mechanism: Predicted circRNA-miRNA interactions projected onto immune-cell-specific enrichment profiles (computational prediction) for flipped circRNAs.
Biological pathway or process:

immune regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circASPH(2,3).1 is a direction-flipping circRNA across timepoints in the COVID-19 non-survivor vs survivor comparison and is included in a predicted circRNA-miRNA-immune cell network. Its proposed immune relevance is based on computational prediction/enrichment rather than experimental validation.
Confidence score:

0.1768
Other information
Title:

circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort.

Journal: Genes
Published: 2025
PubMed ID: 41595454
Study type:

bioinformatics study
Data availability: GSE273149
Code availability: -