circRNA basic information
circBase ID: hsa_circ_0001566
Name: hsa_circ_MAPK9
Synonym: circMAPK9
Host Gene: MAPK9
Genomic location(hg19): chr5:179688683-179707608:-
Genomic location(hg38): chr5:180261683-180280608:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: Rheumatoid arthritis
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

synovial tissues
Cell lines:

RA-FLSs; H-FLSs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PPM1A
Associated microRNA: miR-140-3p
Biological function: Promotes RA-FLS proliferation, migration, invasion and inflammatory response; inhibits apoptosis (knockdown shows opposite effects).
Molecular mechanism: Acts as a miRNA sponge for miR-140-3p to regulate PPM1A expression (ceRNA).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); inflammation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; MTT; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; ELISA; Western Blot; Luciferase Reporter Assay; Clinical Sample Validation
Clinical significance:

-
Description:

circMAPK9 is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS proliferation, migration/invasion and inflammatory cytokine production while inhibiting apoptosis by acting as a ceRNA sponge for miR-140-3p to increase PPM1A expression.
Confidence score:

0.6971
Other information
Title:

CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis.

Journal: Journal of orthopaedic surgery and research
Published: 2021
PubMed ID: 34154607
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -