circRNA basic information
circBase ID: -
Name: hsa_circ_ANKRD12
Synonym: circANKRD12(S8).1
Host Gene: ANKRD12
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: COVID-19 / Coronavirus disease 2019
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Increased in COVID-19 survivors; predicted miRNA interactors showed no immune cell signature enrichment, suggesting a different functional role from mortality-associated candidates.
Molecular mechanism: Predicted circRNA-miRNA interactions assessed via circAtlas 3.0 and MiEAA immune-cell enrichment (no enrichment observed).
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Potentially associated with survival status (higher in survivors) in the mortality-focused comparison.
Description:

circANKRD12(S8).1 is significantly increased in COVID-19 survivors versus non-survivors in a two-timepoint precision-weighted PBMC RNA-seq analysis. Predicted miRNA-interactor analysis found no immune-cell enrichment, implying it may mark survival-associated biology distinct from the immune-dysregulation-linked candidates.
Confidence score:

0.1768
Other information
Title:

circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort.

Journal: Genes
Published: 2025
PubMed ID: 41595454
Study type:

bioinformatics study
Data availability: GSE273149
Code availability: -