circRNA basic information
circBase ID: -
Name: hsa_circ_CDYL
Synonym: circCDYL(2).1
Host Gene: CDYL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: COVID-19 / Coronavirus disease 2019
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with COVID-19 mortality-linked differences and may indicate long-lasting immune or inflammatory changes; computationally linked to PBMC subset-related miRNA enrichment.
Molecular mechanism: Predicted circRNA-miRNA interactions projected onto immune-cell-specific enrichment profiles (computational prediction).
Biological pathway or process:

immune regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Candidate prognostic marker distinguishing COVID-19 non-survivors from survivors in a longitudinal PBMC RNA-seq cohort.
Description:

circCDYL(2).1 is significantly increased in COVID-19 non-survivors versus survivors in a two-timepoint precision-weighted PBMC RNA-seq analysis. Predicted miRNA-binding and immune-cell enrichment analyses suggest potential involvement in systemic immune dysregulation, but this remains computational and needs experimental validation.
Confidence score:

0.1768
Other information
Title:

circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort.

Journal: Genes
Published: 2025
PubMed ID: 41595454
Study type:

bioinformatics study
Data availability: GSE273149
Code availability: -