| Expression pattern: |
UP |
| Associated gene: |
SOX9, CTNNB1, COL10A1 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
Promotes GC cell proliferation, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a molecular sponge for miR-432-5p to derepress SOX9, increasing SOX9 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); Wnt/beta-catenin (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Clinical Sample Validation |
| Clinical significance: |
High expression of circ_0075825 was associated with higher T-stage and lymphatic metastasis in GC patients. |
| Description: |
circ_0075825 is up-regulated in gastric cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. It functions as a ceRNA by sponging miR-432-5p to increase SOX9 expression, with downstream effects including increased CTNNB1 (beta-catenin) and COL10A1. |
| Confidence score: |
0.6815 |