| Expression pattern: |
UP |
| Associated gene: |
CCNB1 |
| Associated microRNA: |
hsa-miR-5683 |
| Biological function: |
Oncogenic; proposed to promote cell cycle progression in gastric cancer via the miR-5683/CCNB1 ceRNA axis. |
| Molecular mechanism: |
ceRNA (miRNA sponging) of hsa-miR-5683 leading to increased CCNB1. |
| Biological pathway or process: |
cell cycle (promotes); ceRNA regulation (promotes); proliferation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Associated with histological grade, lymphatic invasion, perineural invasion, and lymph node involvement; strong diagnostic potential (AUC 0.9355; combined axis AUC 0.9912). |
| Description: |
hsa_circ_0004789 is up-regulated in gastric cancer tissues and is proposed to sponge hsa-miR-5683 to increase CCNB1 expression, supporting a ceRNA model linked to cell-cycle progression. It shows strong diagnostic performance (including combined ROC AUC 0.9912) and correlates with several clinicopathological features; higher expression trends toward worse survival though not statistically significant in this cohort. |
| Confidence score: |
0.5534 |