| Expression pattern: |
DS |
| Associated gene: |
RRM2 |
| Associated microRNA: |
hsa_miR338-5p |
| Biological function: |
Promotes prostate cancer cell proliferation, migration and invasion, and contributes to enzalutamide resistance; knockdown inhibits progression and reverses Enz-resistance in vitro. |
| Molecular mechanism: |
Putative ceRNA mechanism: hsa_circ_0047641 sponges hsa_miR338-5p to regulate RRM2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay |
| Clinical significance: |
- |
| Description: |
In this study, hsa_circ_0047641 was implicated in prostate cancer progression and enzalutamide resistance. It is mainly cytoplasmic and was analyzed as part of a proposed ceRNA subnetwork (hsa_circ_0047641/hsa_miR338-5p/RRM2). Silencing hsa_circ_0047641 reduced proliferation, migration/invasion, and enzalutamide-resistant cell growth in vitro. |
| Confidence score: |
0.508 |