circRNA basic information
circBase ID: hsa_circ_0043256
Name: hsa_circ_ACACA
Synonym: circ_0043256 / hsa_circACACA_033
Host Gene: ACACA
Genomic location(hg19): chr17:35604934-35609962:-
Genomic location(hg38): chr17:37248010-37253036:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues / non-tumor margin tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CCNB1
Associated microRNA: hsa-miR-28-5p
Biological function: Oncogenic; may promote cell cycle progression in gastric cancer via a ceRNA mechanism involving CCNB1.
Molecular mechanism: ceRNA (miRNA sponging) of hsa-miR-28-5p leading to increased CCNB1.
Biological pathway or process:

cell cycle (promotes); ceRNA regulation (promotes); proliferation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Associated with lymphatic invasion; evaluated as diagnostic biomarker by ROC (AUC 0.7280).
Description:

hsa_circ_0043256 is up-regulated in gastric cancer tissues and is proposed to act as a ceRNA sponge for hsa-miR-28-5p, relieving repression of CCNB1 and thereby supporting cell-cycle progression. It shows diagnostic value by ROC analysis and is associated with lymphatic invasion in the patient cohort.
Confidence score:

0.5534
Other information
Title:

Integrated bioinformatics and tissue-based validation reveal the oncogenic role of hsa_circ_0043256 and hsa_circ_0004789 in gastric cancer.

Journal: Biochemistry and biophysics reports
Published: 2026
PubMed ID: 41568058
Study type:

combined biological and clinical study
Data availability: TCGA-STAD; GSE93541; GSE78092
Code availability: -